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Antimicrob Agents Chemother. 1990 June; 34(6): 1271-1272

Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.

Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.

ABSTRACT

Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.

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