This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Gottfredsson, M Articles by Gudmundsson, S Search for Related Content PubMed PubMed Citation Articles by Gottfredsson, M Articles by Gudmundsson, S

 Previous Article

Antimicrob Agents Chemother. 1991 December; 35(12): 2658-2661

Quantitation of postantibiotic effect by measuring CO2 generation of bacteria with the BACTEC blood culture system.

M Gottfredsson, H Erlendsdottir and S Gudmundsson

Department of Internal Medicine, Borgarspitalinn, Reykjavik, Iceland.

ABSTRACT

The duration of the postantibiotic effect (PAE) determined by bacterial CO2 production measured by using the BACTEC NR 730 blood culture system was compared with PAEs determined by standard viability counting. PAEs for Staphylococcus aureus after exposure to dicloxacillin, vancomycin, rifampin, gentamicin, and ciprofloxacin and for Escherichia coli after exposure to ampicillin, gentamicin, and ciprofloxacin were quantitated by the two methods, and an excellent correlation (r = 0.93) was demonstrated. The difference in the PAE durations determined by the two methods was 0.1 +/- 0.4 (mean +/- standard deviation) h. Thus, the BACTEC CO2 generation method provides a simple, alternate way of determining the PAE in vitro.

---

Antimicrob Agents Chemother. 1991 December; 35(12): 2658-2661

This article has been cited by other articles:

• Dominguez, M. C., de la Rosa, M., Borobio, M. V. (2001). Application of a spectrophotometric method for the determination of post-antibiotic effect and comparison with viable counts in agar. J Antimicrob Chemother 47: 391-398 [Abstract] [Full Text]