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Antimicrob Agents Chemother. 1992 November; 36(11): 2478-2480

Pharmacokinetics of a clarithromycin suspension in infants and children.

V N Gan, S Y Chu, H T Kusmiesz and J C Craft

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063.

ABSTRACT

The single- and multiple-dose pharmacokinetics of clarithromycin and its 14-(R)-hydroxylated metabolite in infants and children were studied after oral administration under fasting and nonfasting conditions. Drug absorption appeared to be rapid following a brief delay in its onset; the mean peak concentrations in plasma (Cmax) for clarithromycin were reached within about 3 h under both conditions. The mean Cmax for the parent drug were 3.59 and 4.58 micrograms/ml in single-dose fasting and nonfasting patients, and the respective Cmax for the metabolite were 1.19 and 1.26 micrograms/ml. Data indicate good absorption and no significant effects by food. There was no unusual accumulation in the area under the concentration-time curve and Cmax in the multiple-dose group.

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Antimicrob Agents Chemother. 1992 November; 36(11): 2478-2480