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Antimicrob Agents Chemother. 1992 July; 36(7): 1580-1583
Copyright © 1992, American Society for Microbiology. All Rights Reserved.

Evaluation of the Usefulness of a Novel Injectable Cephalosporin, E1040, and Ceftazidime for Management of Complicated Urinary Tract Infections Caused by Pseudomonas aeruginosa and Proteus mirabilis by Using the Rat Urolithiasis Model

Masaru Satoh*, Kei-Ichi Munakata, Hideo Takeuchi and Osamu Yoshida

1 Department of Microbiology, Tokyo Research Laboratories, Eisai Co., Ltd., 4 Koishikawa, Bunkyo-ku, Tokyo 112, and Department of Urology, Faculty of Medicine, Kyoto University, 54 Kawara-machi, Shogoin, Sakyo-ku, Kyoto 606,2 Japan

ABSTRACT

A novel injectable cephalosporin, E1040, significantly eradicated Pseudomonas aeruginosa from the urine, in contrast to ceftazidime, in rats with complicated P. aeruginosa urinary tract infections associated with urinary stones, suggesting that E1040 is a prospective therapeutic agent in the management of refractory Pseudomonas urinary tract infections.

FOOTNOTES

* Corresponding author.

Antimicrob Agents Chemother. 1992 July; 36(7): 1580-1583
Copyright © 1992, American Society for Microbiology. All Rights Reserved.





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