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Antimicrob Agents Chemother. 1993 June; 37(6): 1367-1369

Aerosol amphotericin B for prevention of invasive pulmonary aspergillosis.

J Beyer, G Barzen, G Risse, C Weyer, K Miksits, K Dullenkopf, D Huhn and W Siegert

Abteilung Innere Medizin mit Schwerpunkt Hämatologie und Onkologie, Universitätsklinikum Rudolf Virchow, Freien Universität Berlin, Federal Republic of Germany.

ABSTRACT

The pharmacokinetics and applicability of aerosol amphotericin B administrations were studied in 40 neutropenic patients and 4 healthy volunteers. Particle size was measured and pulmonary deposition was demonstrated by radioisotope studies. Inhalations were easy to administer and were well tolerated, with minimal systemic absorption of the drug.

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Antimicrob Agents Chemother. 1993 June; 37(6): 1367-1369

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