This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Roblin, P M Articles by Hammerschlag, M R Search for Related Content PubMed PubMed Citation Articles by Roblin, P M Articles by Hammerschlag, M R

 Previous Article  |  Next Article 

Antimicrob Agents Chemother. 1994 July; 38(7): 1588-1589

Susceptibilities to clarithromycin and erythromycin of isolates of Chlamydia pneumoniae from children with pneumonia.

P M Roblin, G Montalban and M R Hammerschlag

Department of Pediatrics, SUNY Health Science Center at Brooklyn 11203-2098.

ABSTRACT

We tested in vitro 49 isolates of Chlamydia pneumoniae obtained from 35 children with community-acquired pneumonia against clarithromycin and erythromycin. The children were part of a treatment study comparing the two drugs. Clarithromycin was 2- to 10-fold more active than erythromycin, with a MIC for 90% of strains tested and minimal chlamydiacidal concentration for 90% of strains tested of 0.031 microgram/ml compared with 0.125 microgram/ml for erythromycin. Eight of these children, two of whom were treated with erythromycin and six of whom received clarithromycin, remained culture positive after treatment. We were able to test 21 isolates from these children. All were susceptible to both drugs, and the MICs did not change after therapy.

---

Antimicrob Agents Chemother. 1994 July; 38(7): 1588-1589

This article has been cited by other articles:

• Binet, R., Maurelli, A. T. (2005). Frequency of Spontaneous Mutations That Confer Antibiotic Resistance in Chlamydia spp.. Antimicrob. Agents Chemother. 49: 2865-2873 [Abstract] [Full Text]  
• Pelton, S. I., Hammerschlag, M. R. (2005). Overcoming Current Obstacles in the Management of Bacterial Community-Acquired Pneumonia in Ambulatory Children. CLIN PEDIATR 44: 1-17  
• Tormakangas, L., Alakarppa, H., David, D. B., Leinonen, M., Saikku, P. (2004). Telithromycin Treatment of Chronic Chlamydia pneumoniae Infection in C57BL/6J mice. Antimicrob. Agents Chemother. 48: 3655-3661 [Abstract] [Full Text]  
• Riska, P. F., Kutlin, A., Ajiboye, P., Cua, A., Roblin, P. M., Hammerschlag, M. R. (2004). Genetic and Culture-Based Approaches for Detecting Macrolide Resistance in Chlamydia pneumoniae. Antimicrob. Agents Chemother. 48: 3586-3590 [Abstract] [Full Text]  
• Yamaguchi, H., Friedman, H., Yamamoto, M., Yasuda, K., Yamamoto, Y. (2003). Chlamydia pneumoniae Resists Antibiotics in Lymphocytes. Antimicrob. Agents Chemother. 47: 1972-1975 [Abstract] [Full Text]  
• Morrissey, I., Salman, H., Bakker, S., Farrell, D., Bebear, C. M., Ridgway, G. (2002). Serial passage of Chlamydia spp. in sub-inhibitory fluoroquinolone concentrations. J Antimicrob Chemother 49: 757-761 [Abstract] [Full Text]  
• Boman, J., Hammerschlag, M. R. (2002). Chlamydia pneumoniae and Atherosclerosis: Critical Assessment of Diagnostic Methods and Relevance to Treatment Studies. Clin. Microbiol. Rev. 15: 1-20 [Abstract] [Full Text]  
• Strigl, S., Roblin, P. M., Reznik, T., Hammerschlag, M. R. (2000). In Vitro Activity of ABT 773, a New Ketolide Antibiotic, against Chlamydia pneumoniae. Antimicrob. Agents Chemother. 44: 1112-1113 [Abstract] [Full Text]  
• Roblin, P. M., Hammerschlag, M. R. (1998). Microbiologic Efficacy of Azithromycin and Susceptibilities to Azithromycin of Isolates of Chlamydia pneumoniae from Adults and Children with Community-Acquired Pneumonia. Antimicrob. Agents Chemother. 42: 194-196 [Abstract] [Full Text]