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Antimicrobial Agents and Chemotherapy, 02 1995, 561-563, Vol 39, No. 2
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae

T Deguchi, M Yasuda, M Asano, K Tada, H Iwata, H Komeda, T Ezaki, I Saito and Y Kawada
Department of Urology, Gifu University, Japan.

Eight quinolone-resistant clinical isolates of Neisseria gonorrhoeae were shown to carry mutations in their GyrA proteins. Six isolates had a single amino acid change of serine to phenylalanine at the position corresponding to Ser-83 in Escherichia coli. In addition to the change of serine to phenylalanine, two isolates had another change of aspartic acid to asparagine at the position corresponding to Asp-87 in E. coli.


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