This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gangadharam, P. R.
Right arrow Articles by Duzgunes, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gangadharam, P. R.
Right arrow Articles by Duzgunes, N.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, 03 1995, 725-730, Vol 39, No. 3
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Therapy of Mycobacterium avium complex infections in beige mice with streptomycin encapsulated in sterically stabilized liposomes

PR Gangadharam, DR Ashtekar, DL Flasher and N Duzgunes
Department of Medicine, University of Illinois at Chicago, College of Medicine 60612, USA.

Mycobacterium avium complex (MAC) causes serious opportunistic infections in AIDS patients. Previous studies with MAC-infected beige mice have indicated that weekly administration of liposome-encapsulated streptomycin can reduce significantly the CFU in the liver and spleen. We examined whether streptomycin encapsulated in recently developed sterically stabilized liposomes with prolonged circulation times would have a therapeutic effect in this animal model. Two liposome types with prolonged circulation (polyethyleneglycol- distearoylphosphatidylethanolamine [PEG-DSPE]- distearoylphosphatidylcholine [DSPC]-cholesterol [chol] or phosphatidylinositol [PI]-DSPC-chol) and conventional liposomes (phosphatidylglycerol [PG]-phosphatidylcholine [PC]-chol) encapsulating streptomycin and administered twice weekly were bactericidal to MAC strain 101 in the spleen when the level of infection after treatment was compared with the level of infection before treatment. PI-DSPC-chol and PG-PC-chol liposomes encapsulating streptomycin were bactericidal in the liver. Although PG-PC-chol or PEG-DSPE-DSPE-chol liposomes encapsulating streptomycin were not bactericidal in the lungs, they reduced the level of MAC infection by more than 3 orders of magnitude compared with the level of MAC infection in untreated controls.


This article has been cited by other articles:

  • de Steenwinkel, J. E. M., van Vianen, W., ten Kate, M. T., Verbrugh, H. A., van Agtmael, M. A., Schiffelers, R. M., Bakker-Woudenberg, I. A. J. M. (2007). Targeted drug delivery to enhance efficacy and shorten treatment duration in disseminated Mycobacterium avium infection in mice. J Antimicrob Chemother 60: 1064-1073 [Abstract] [Full Text]  
  • Vakulenko, S. B., Mobashery, S. (2003). Versatility of Aminoglycosides and Prospects for Their Future. Clin. Microbiol. Rev. 16: 430-450 [Abstract] [Full Text]  
  • Schiffelers, R., Storm, G., Bakker-Woudenberg, I. (2001). Liposome-encapsulated aminoglycosides in pre-clinical and clinical studies. J Antimicrob Chemother 48: 333-344 [Abstract] [Full Text]  
  • Gaspar, M. M., Neves, S., Portaels, F., Pedrosa, J., Silva, M. T., Cruz, M. E. M. (2000). Therapeutic Efficacy of Liposomal Rifabutin in a Mycobacterium avium Model of Infection. Antimicrob. Agents Chemother. 44: 2424-2430 [Abstract] [Full Text]  
  • Quenelle, D. C., Staas, J. K., Winchester, G. A., Barrow, E. L. W., Barrow, W. W. (1999). Efficacy of Microencapsulated Rifampin in Mycobacterium tuberculosis-Infected Mice. Antimicrob. Agents Chemother. 43: 1144-1151 [Abstract] [Full Text]  
  • Barrow, E. L. W., Winchester, G. A., Staas, J. K., Quenelle, D. C., Barrow, W. W. (1998). Use of Microsphere Technology for Targeted Delivery of Rifampin to Mycobacterium tuberculosis-Infected Macrophages. Antimicrob. Agents Chemother. 42: 2682-2689 [Abstract] [Full Text]  
  • Brun-Pascaud, M., Rajagopalan-Levasseur, P., Chau, F., Bertrand, G., Garry, L., Derouin, F., Girard, P.-M. (1998). Drug Evaluation of Concurrent Pneumocystis carinii, Toxoplasma gondii, and Mycobacterium avium Complex Infections in a Rat Model. Antimicrob. Agents Chemother. 42: 1068-1072 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»