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Antimicrobial Agents and Chemotherapy, 03 1995, 746-749, Vol 39, No. 3
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

(R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine is a potent inhibitor of feline immunodeficiency virus infection

TW Vahlenkamp, A De Ronde, J Balzarini, L Naesens, E De Clercq, MJ van Eijk, MC Horzinek and HF Egberink
Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.

The antiviral efficacy of acyclic nucleoside phosphonates, including 9- (2-phosphonylmethoxyethyl)adenine (PMEA) and (R)-9-(2- phosphonylmethoxypropyl)-2,6-diaminopurine [(R)-PMPDAP] against feline immunodeficiency virus (FIV) infection was determined. (R)-PMPDAP showed the highest selectivity index (> 2,000) in vitro. Treatment of experimentally FIV-infected asymptomatic cats with PMEA or (R)-PMPDAP had no effect on the CD4+/CD8+ ratio. However, mean plasma viral RNA concentrations decreased significantly in the (R)-PMPDAP-treated cats. Our data show that, in comparison to PMEA, (R)-PMPDAP is a more potent and less toxic inhibitor of FIV replication both in vitro and in vivo.

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