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Antimicrobial Agents and Chemotherapy, Jul 1995, 1589-1590, Vol 39, No. 7
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

In vitro activity of the semisynthetic glycopeptide amide MDL 63,246

MT Kenny, MA Brackman and JK Dulworth
Marion Merrell Dow Inc., Kansas City, Missouri 64134-0627, USA.

The in vitro activity of the semisynthetic glycopeptide amide MDL 63,246 against 293 U.S. clinical isolates of gram-positive cocci was determined by the broth microdilution method. When compared with teicoplanin, MDL 63,246 had improved activity against Staphylococcus epidermidis (MICs that inhibited 90% strains tested [MIC90s], 0.25 versus 8 micrograms/ml, respectively). Staphylococcus haemolyticus (MIC90s, 1 versus 32 micrograms/ml, respectively), and VanA Enterococcus faecium (MIC90s, 32 versus > or = 1,024 micrograms/ml, respectively).

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