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Antimicrobial Agents and Chemotherapy, 07 1995, 1599-1602, Vol 39, No. 7
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Activity of penciclovir against Epstein-Barr virus

TH Bacon and MR Boyd
SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, United Kingdom.

Penciclovir inhibited the productive replication cycle of Epstein-Barr virus (EBV) in assays measuring infectious virus production, viral antigen expression, and viral DNA synthesis. In the test measuring inhibition of EBV DNA synthesis, 50% effective concentrations of penciclovir and acyclovir were 2.3 +/- 0.8 and 2.2 +/- 0.6 micrograms/ml, respectively. The 50% cell growth inhibitory concentration of penciclovir was > 100 micrograms/ml for both P3HR-1 and Raji cells. Penciclovir is a selective inhibitor of EBV in cell culture.


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