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Antimicrobial Agents and Chemotherapy, Jul 1995, 1603-1605, Vol 39, No. 7
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Quinine plus clindamycin improves chemotherapy of severe malaria in children

PG Kremsner, P Radloff, W Metzger, E Wildling, B Mordmuller, J Philipps, L Jenne, M Nkeyi, J Prada and U Bienzle
International Research Laboratory, Albert-Schweitzer-Hospital, Lambarene, Gabon.

In a randomized trial, a 4-day quinine-clindamycin regimen was compared with the standard 7-day quinine regimen for 100 Gabonese children (50 children in each group) with severe Plasmodium falciparum malaria. In each group, only one patient died. Parasite clearance and fever clearance times were significantly shorter in the quinine-clindamycin group (P = 0.03 and P = 0.01, respectively) than in the quinine group, and significantly more recurring fever episodes occurred in the quinine group than in the quinine-clindamycin group shortly after initial fever clearance and parasite clearance (P < 0.001).


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