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Antimicrobial Agents and Chemotherapy, 08 1995, 1866-1870, Vol 39, No. 8
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Early detection of rifampin in human nerve tissue after an oral dose of 600 milligrams

M Guebre-Xabier, EJ Shannon, R Kazen, Z Kebret and D Frommel
Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue.




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