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Antimicrobial Agents and Chemotherapy, 08 1995, 1881-1884, Vol 39, No. 8
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

OXA-14, another extended-spectrum variant of OXA-10 (PSE-2) beta- lactamase from Pseudomonas aeruginosa

F Danel, LM Hall, D Gur and DM Livermore
Department of Medical Microbiology, London Hospital Medical College, United Kingdom.

Pseudomonas aeruginosa 455, isolated in Ankara, Turkey, produced a pI 6.2 beta-lactamase determined by plasmid pMLH53 and resisted all beta- lactams except carbapenems. This beta-lactamase, named OXA-14, corresponded to OXA-10 (PSE-2) except that aspartate replaced glycine at position 157 and thus is intermediate between OXA-10 and OXA-11, which has aspartate at position 157 and a further substitution at position 143.


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