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Antimicrobial Agents and Chemotherapy, 09 1995, 2138-2140, Vol 39, No. 9
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Influence of a newly developed quinolone, T-3761, on pharmacokinetics of theophylline in rats

T Hasegawa, M Nadai, S Haghgoo, K Yamaki, K Takagi and T Nabeshima
Department of Hospital Pharmacy, Nagoya University School of Medicine, Japan.

The effect of a new quinolone, T-3761, on the pharmacokinetics and metabolism of theophylline was investigated with rats. T-3761 at a high dose (20 mg/kg of body weight) was injected intravenously 10 min before an intravenous administration of theophylline (10 mg/kg). The presence of T-3761 slightly delayed the disappearance of theophylline from plasma. Parameters related to the pharmacokinetic interaction between theophylline and T-3761 were estimated by noncompartmental methods. A significant decrease (approximately 25%) in the systemic clearance of theophylline was observed in the presence of T-3761. However, no significant changes between the control group and the T-3761-treated groups in the volume of distribution at a steady state were observed. Pretreatment with T-3761 increased the urinary excretion of unchanged theophylline (by approximately 25%) and decreased the nonrenal clearances (by approximately 30%), indicating that T-3761 inhibits the metabolism of theophylline. These findings suggest that T-3761 at the dose used in this study affects the pharmacokinetics and metabolism of theophylline.




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