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Antimicrobial Agents and Chemotherapy, 11 1996, 2658-2660, Vol 40, No. 11
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Biliary excretion of ciprofloxacin and piperacillin in the obstructed biliary tract

SJ van den Hazel, XH de Vries, P Speelman, J Dankert, GN Tytgat, K Huibregtse and DJ van Leeuwen
Department of Gastroenterology and Hepatology, University of Amsterdam, The Netherlands.

Biliary excretion of ciprofloxacin and piperacillin was determined in cholestatic patients who had undergone endoscopic cholangiography. The median concentration of ciprofloxacin (n = 9) was 2.36 micrograms/ml (range, 0.29 to 19.8 micrograms/ml) in bile compared with 1.66 micrograms/ml (range, 0.73 to 2.69 micrograms/ml) in serum. The median concentration of piperacillin (n = 7) was < 5 micrograms/ml (range, < 5 to 26) in bile compared with 14.3 micrograms/ml (range, 5.3 to 80) in serum. Ciprofloxacin, but not piperacillin, can be actively excreted into bile in the presence of a biliary tract obstruction.

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