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Antimicrobial Agents and Chemotherapy, 12 1996, 2805-2808, Vol 40, No. 12
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Comparative serum bactericidal activities of ceftizoxime and cefotaxime against intermediately penicillin-resistant Streptococcus pneumoniae

KB Patel, DP Nicolau, CH Nightingale and R Quintiliani
Department of Pharmacy Practice, Arnold and Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, New York 11201, USA.

In a randomized crossover study involving 12 healthy volunteers, 1 g of ceftizoxime or cefotaxime was administered intravenously every 12 h for a total of three doses on two separate weekends. The duration of serum bactericidal titers (SBTs) greater than 1:2 and the time serum drug concentrations remained above the MIC (T > MIC) were determined against three clinical isolates of Streptococcus pneumoniae with intermediate resistance to penicillin. The duration of SBTs and T > MIC for both antimicrobial agents exceeded 50% of the dosing interval for all isolates. Ceftizoxime's T > MIC was statistically greater than that of cefotaxime, indicating that its longer half-life in serum (1.7 h) compared with that of cefotaxime (approximately 1 h) compensates for its slightly lower microbiologic activity against the penicillin- resistant pneumococci tested in this study.


This article has been cited by other articles:

  • Waites, K. B., Rivers;, T., Quintiliani, R. (1998). Bactericidal Activities of Ceftizoxime and Cefotaxime against Streptococcus pneumoniae. Antimicrob. Agents Chemother. 42: 1869-1870 [Full Text]  


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