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Antimicrobial Agents and Chemotherapy, 12 1996, 2887-2890, Vol 40, No. 12
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Genotypic and phenotypic changes during culture of a multinucleoside- resistant human immunodeficiency virus type 1 strain in the presence and absence of additional reverse transcriptase inhibitors

RW Shafer, MA Winters, AK Iversen and TC Merigan
Division of Infectious Diseases and Geographic Medicine, Stanford University, California 94305, USA.

The observation that human immunodeficiency virus type 1 (HIV-1) mutations conferring resistance to one reverse transcriptase (RT) inhibitor may suppress resistance to other RT inhibitors provides a rationale for treating HIV-1 with certain RT inhibitor combinations. We examined phenotypic and genotypic changes during culture of a multinucleoside (zidovudine, didanosine, zalcitibine, and stavudine)- resistant HIV-1 strain with and without additional RT inhibitors (nevirapine and lamivudine). The development of nevirapine or lamivudine resistance by the multinucleoside-resistant strain was not accompanied by a reduction in zidovudine or didanosine resistance.


This article has been cited by other articles:

  • Shafer, R. W. (2002). Genotypic Testing for Human Immunodeficiency Virus Type 1 Drug Resistance. Clin. Microbiol. Rev. 15: 247-277 [Abstract] [Full Text]  
  • Winters, M. A., Coolley, K. L., Cheng, P., Girard, Y. A., Hamdan, H., Kovari, L. C., Merigan, T. C. (2000). Genotypic, Phenotypic, and Modeling Studies of a Deletion in the beta 3-beta 4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors. J. Virol. 74: 10707-10713 [Abstract] [Full Text]  


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