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Antimicrobial Agents and Chemotherapy, 02 1996, 477-480, Vol 40, No. 2
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Mutations in 23S rRNA are associated with clarithromycin resistance in Helicobacter pylori

J Versalovic, D Shortridge, K Kibler, MV Griffy, J Beyer, RK Flamm, SK Tanaka, DY Graham and MF Go
Division of Digestive Diseases, Baylor College of Medicine, Houston, Texas, USA. jamesv@bcm.tmc.edu

Twelve clarithromycin-resistant Helicobacter pylori isolates (100% of resistant isolates examined) from seven different patients each contained an A-->G transition mutation within a conserved loop of 23S rRNA. A-->G transition mutations at positions cognate with Escherichia coli 23S rRNA positions 2058 and 2059 were identified. Clarithromycin- susceptible H. pylori isolates from 14 different patients displayed no polymorphisms in a conserved loop within domain V of 23S rRNA. The study is the first to report mutations in H. pylori associated with resistance to an antimicrobial agent used in established peptic ulcer treatment regimens.


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