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Antimicrobial Agents and Chemotherapy, 03 1996, 822-824, Vol 40, No. 3
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

In vitro susceptibilities of clinical and environmental isolates of Cryptococcus neoformans to five antifungal drugs

SP Franzot and JS Hamdan
Department of Microbiology, Federal University of Minas Gerais, Brazil. franzot@oraculo.lcc.ufmg.br

A total of 53 Cryptococcus neoformans strains, including clinical and environmental Brazilian isolates, were tested for their susceptibilities to amphotericin B, 5-flucytosine, ketoconazole, fluconazole, and itraconazole. The tests were performed according to the National Committee of Clinical Laboratory Standards recommendations (document M27-P). In general, there was a remarkable homogeneity of results for all strains, and comparable MICs were found for environmental and clinical isolates. This paper represents the first contribution in which susceptibility data for Brazilian C. neoformans isolates are provided.


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