This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Nishihara, K. Articles by Iga, T. Search for Related Content PubMed PubMed Citation Articles by Nishihara, K. Articles by Iga, T.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, May 1996, 1098-1103, Vol 40, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Lack of effect of vancomycin and gentamicin on auditory function in guinea pigs

K Nishihara, T Shimizu, H Kotaki, Y Sawada, T Okuno, K Kaga, T Murofushi and T Iga
Department of Pharmacy, Faculty of Medicine, University of Tokyo Hospital, Japan.

The dispositions of vancomycin (VCM) and gentamicin (GM) in plasma and perilymph after single and multiple administrations and the effects of multiple administrations of VCM or GM alone and the combination of both drugs on auditory function were studied in male guinea pigs. The pharmacokinetic parameters of VCM and GM obtained from plasma drug concentration-time data after single and multiple (22 days) intramuscular administrations of VCM (200 mg/kg of body weight) alone and GM (50 mg/kg) alone were not significantly different from those after combined administration of VCM (200 mg/kg) and GM (50 mg/kg). There was no change in the penetration ratio of VCM and GM into perilymph between administration of VCM or GM alone and the combination of both drugs. Furthermore, the hearing threshold of guinea pigs was not affected by VCM or GM alone or the combination of both drugs within the range of therapeutic VCM and GM levels in plasma in humans.