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Antimicrobial Agents and Chemotherapy, May 1996, 1289-1293, Vol 40, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins

JC Fung-Tomc, E Gradelski, E Huczko, TJ Dougherty, RE Kessler and DP Bonner
Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA.

The rates of development of resistance to ceftriaxone, ceftazidime, cefepime, and cefpirome in 10 strains of Enterobacter cloacae were determined by daily transfer for 7 days to fresh medium containing twofold serial dilutions of the antibiotics. Development of resistance to ceftriaxone was the most rapid; this was followed by ceftazidime, cefpirome, and cefepime. Resistant variants selected by ceftriaxone and ceftazidime were cross-resistant and produced very high levels of beta- lactamase. On the other hand, resistant variants selected by cefepime and cefpirome often had moderately high levels of beta-lactamase and diminished levels of the 39- to 40-kDa porin protein.


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