This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Viora, M. Articles by Ortona, E. Search for Related Content PubMed PubMed Citation Articles by Viora, M. Articles by Ortona, E.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, 05 1996, 1294-1297, Vol 40, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

In vitro and in vivo immunomodulatory effects of anti-Pneumocystis carinii drugs

M Viora, A De Luca, A D'Ambrosio, A Antinori and E Ortona
Department of Immunology, Istituto Superiore di Sanita, Rome, Italy.

The anti-Pneumocystis carinii drug effects on mitogen-, antigen-, and interleukin-2-induced proliferative responses and on natural killer (NK) cell-mediated activity were analyzed in vivo (rats) and in vitro (normal human peripheral blood mononuclear cells). Splenocytes derived from in vivo piritrexim- and clindamycin-treated rats showed a significant inhibition of mitogen-induced proliferative responses. In vitro exposure to clindamycin, piritrexim, and pyrimethamine caused an inhibition of human T lymphocyte proliferation in response to mitogen, antigen, and interleukin-2 stimulation. Rat NK cell-mediated cytotoxic activity was not affected by the drugs, and human NK cell activity was reduced only at the highest concentration (10 micrograms/ml) of the drugs. The potential immunotoxicity of the long-term administration of these agents in humans needs further investigation.

This article has been cited by other articles:

• Giammarioli, A. M., Maselli, A., Casagrande, A., Gambardella, L., Gallina, A., Spada, M., Giovannetti, A., Proietti, E., Malorni, W., Pierdominici, M. (2008). Pyrimethamine Induces Apoptosis of Melanoma Cells via a Caspase and Cathepsin Double-Edged Mechanism. Cancer Res. 68: 5291-5300 [Abstract] [Full Text]  
• Pierdominici, M., Giammarioli, A. M., Gambardella, L., De Felice, M., Quinti, I., Iacobini, M., Carbonari, M., Malorni, W., Giovannetti, A. (2005). Pyrimethamine (2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine) Induces Apoptosis of Freshly Isolated Human T Lymphocytes, Bypassing CD95/Fas Molecule but Involving Its Intrinsic Pathway. J. Pharmacol. Exp. Ther. 315: 1046-1057 [Abstract] [Full Text]  
• Freund, Y. R., Dousman, L., MacGregor, J. T., Mohagheghpour, N. (2000). Oral Treatment with Trimethoprim-Sulfamethoxazole and Zidovudine Suppresses Murine Accessory Cell-Dependent Immune Responses. Toxicol Sci 55: 335-342 [Abstract] [Full Text]