This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Wood, P. J. Articles by McLean, A. J. Search for Related Content PubMed PubMed Citation Articles by Wood, P. J. Articles by McLean, A. J.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, 05 1996, 1321-1324, Vol 40, No. 5
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Kill kinetics and regrowth patterns of Pseudomonas aeruginosa exposed to concentration-time profiles of tobramycin simulating in vivo infusion and bolus dosing

PJ Wood, LL Ioannides-Demos, EB Bastone, WJ Spicer and AJ McLean
Department of Clinical Pharmacology, Monash University Department of Microbiology, Prahran, Victoria, Australia.

Pseudomonas aeruginosa ATCC 27853 was exposed to tobramycin concentration-time profiles modelling in vivo bolus and infusion dosing. Dependence of bactericidal and bacteriostatic activity on the initial profile of peak concentration (bolus effect > infusion) and area under the antibiotic concentration-time curve was observed at peak concentration/MIC ratios of 10 or below.

This article has been cited by other articles:

• Ioannides-Demos, L. L., Liolios, L., Wood, P., Spicer, W. J., McLean, A. J. (1998). Changes in MIC Alter Responses of Pseudomonas aeruginosa to Tobramycin Exposure. Antimicrob. Agents Chemother. 42: 1365-1369 [Abstract] [Full Text]  
• Rayner, C. R., Ioannides-Demos, L. L., Brien, J.-A. E., Liolios, L. L., Spicer, W. J. (1998). Initial Concentration-Time Profile of Gentamicin Determines Efficacy against Enterobacter cloacae ATCC 13047. Antimicrob. Agents Chemother. 42: 1370-1374 [Abstract] [Full Text]