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Next Article 

Antimicrobial Agents and Chemotherapy, Jun 1996, 1331-1334, Vol 40, No. 6
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Didanosine measurement by radioimmunoassay

M DeRemer, R D'Ambrosio and GD Morse
Department of Pharmacy Practice, State University of New York at Buffalo, USA.

Didanosine is commonly prescribed as monotherapy or as part of a combination regimen for patients with human immunodeficiency virus infection. The use of lower doses, either as part of a combination regimen or as a result of dose reduction secondary to clinical intolerance, requires that a sensitive assay method be available for either traditional or population-based pharmacokinetic evaluations. We evaluated a radioimmunoassay technique with a standard curve range of 0 to 100 ng/ml in human plasma, urine, and cerebrospinal fluid and assessed its accuracy and precision for use in pharmacokinetic studies.


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  • Adams, J. M., Shelton, M. J., Hewitt, R. G., Grasela, T. H., DeRemer, M., Morse, G. D. (1998). Relationship between Didanosine Exposure and Surrogate Marker Response in Human Immunodeficiency Virus-Infected Outpatients. Antimicrob. Agents Chemother. 42: 821-826 [Abstract] [Full Text]  


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