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Antimicrobial Agents and Chemotherapy, Aug 1996, 1843-1845, Vol 40, No. 8
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

In vitro activities of azithromycin and doxycycline against 15 isolates of Chlamydia pneumoniae

J Gnarpe, K Eriksson and H Gnarpe
Department of Clinical Microbiology, Gavle Central Hospital, Sweden.

Fourteen isolates of Chlamydia pneumoniae, 12 from clinically ill patients and 2 from subjectively healthy individuals from an area within a 400-km proximity of Gavle, Sweden, and strain IOL-207, originally from the eye of an Iranian child, were tested for susceptibilities to the antibiotics doxycycline and azithromycin. MICs and minimum chlamydiacidal concentrations were found to correlate well with values reported earlier by other investigators. In addition to MIC and minimum chlamydiacidal concentration testing, testing for the viability of C. pneumoniae after exposure to antibiotic concentrations as high as 50 mg/liter was carried out by passaging antibiotic-treated, infected cell cultures four times in the absence of antibiotics. It was found that all Chlamydia strains were viable after four passages, regardless of antibiotic concentration in the cell culture.

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