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Antimicrobial Agents and Chemotherapy, 08 1996, 1941-1944, Vol 40, No. 8
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Characterization of bactericidal activity of clindamycin against Bacteroides fragilis via kill curve methods

ME Klepser, MA Banevicius, R Quintiliani and CH Nightingale
Department of Pharmacy, Hartford Hospital, Connecticut 06102, USA. michael-klepser@uiowa.edu

Kill curves were determined for five isolates of Bacteroides fragilis with clindamycin at concentrations equal to the MIC or to 4, 16, and 64 times the MIC. Examination of plots of log CFU per milliliter versus time revealed no association between the clindamycin concentration and the rate and extent of the bactericidal activity against B. fragilis at or below 64 times the MIC.


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