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Antimicrobial Agents and Chemotherapy, 08 1996, 1953-1956, Vol 40, No. 8
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Sequencing and analysis of four new Enterobacter ampD Alleles

AF Ehrhardt, CC Sanders, JR Romero and JS Leser
Department of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA.

Sequences of ampD genes from wild-type, temperature-sensitive, and stably derepressed mutants of the wild-type strain of Enterobacter cloacae 029 and the hyperinducible strain E. cloacae 1194E were determined and compared with the ampD gene of the wild-type strain E. cloacae 14. Seventy nucleotide differences were found between the wild- type sequences, resulting in 13 amino acid changes. The deduced amino acid changes do not correspond to published AmpC regulation mutations and expand the number of known mutations leading to altered AmpC beta- lactamase expression in members of the family Enterobacteriaceae.


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