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Antimicrobial Agents and Chemotherapy, Sep 1996, 1995-1997, Vol 40, No. 9
Copyright © 1996 by the American Society for Microbiology. All rights reserved.

Gamma radiation-sterilized, triple-lumen catheters coated with a low concentration of chlorhexidine were not efficacious at preventing catheter infections in intensive care unit patients

RJ Sherertz, SO Heard, II Raad, L Gentry, D Bowton, P Scuderi, J Hu, W Carruth, B Satishchandra, J Pepe, A Mosenthal, T Burke and J Dupuis
Section on Infectious Diseases, Bowman Gray School of Medicine, Winston- Salem, North Carolina, USA.

In a randomized, double-blind trial, gamma radiation-sterilized, chlorhexidine-coated triple-lumen catheters were compared with uncoated control catheters for their ability to prevent catheter infection in 254 intensive care unit patients. The chlorhexidine coating was not efficacious, and a rabbit model demonstrated that reduction of chlorhexidine activity by gamma radiation sterilization was the likely explanation for the failure.


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