This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Reprints and Permissions Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Cattani, L. Articles by Orsi, N. Search for Related Content PubMed PubMed Citation Articles by Cattani, L. Articles by Orsi, N.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, Jan 1997, 212-214, Vol 41, No. 1
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Bafilomycin A1 and intracellular multiplication of Legionella pneumophila

L Cattani, P Goldoni, MC Pastoris, L Sinibaldi and N Orsi
Istituto di Microbiologia, Facolta di Medicina e Chirurgia, Universita La Sapienza, Rome, Italy.

Multiplication of Legionella pneumophila in HeLa cells was found to be inhibited by noncytotoxic concentrations of bafilomycin A1, with blockage of bacterial growth at a concentration 15.6 nM. The inhibiting action was evident only when the antibiotic was present during the initial phase of intracellular multiplication, i.e., during the formation of the phagosome, whereas the addition of the drug did not affect microorganisms already actively multiplying within the phagosome.

This article has been cited by other articles:

• Sturgill-Koszycki, S., Swanson, M. S. (2000). Legionella pneumophila Replication Vacuoles Mature into Acidic, Endocytic Organelles. JEM 192: 1261-1272 [Abstract] [Full Text]