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Antimicrobial Agents and Chemotherapy, 01 1997, 215-217, Vol 41, No. 1
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

In vitro susceptibility of Helicobacter pylori to protolichesterinic acid from the lichen Cetraria islandica

K Ingolfsdottir, MA Hjalmarsdottir, A Sigurdsson, GA Gudjonsdottir, A Brynjolfsdottir and O Steingrimsson
Department of Pharmacy, University of Iceland, Reykjavik, Iceland. kring@rhi.hi.is

With reference to the traditional use of Cetraria islandica (Iceland moss) for relief of gastric and duodenal ulcer, plant extracts were screened for in vitro activity against Helicobacter pylori. (+)- Protolichesterinic acid, an aliphatic alpha-methylene-gamma-lactone, was identified as an active component. The MIC range of protolichesterinic acid, in free as well as salt form, was 16 to 64 micrograms/ml.

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