This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nakano, M.
Right arrow Articles by Kawada, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nakano, M.
Right arrow Articles by Kawada, Y.

 Previous Article  |  Next Article 

Antimicrob. Agents Chemother., Oct 1997, 2289-2291, Vol 41, No. 10
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Mutations in the gyrA and parC genes in fluoroquinolone-resistant clinical isolates of Pseudomonas aeruginosa

M Nakano, T Deguchi, T Kawamura, M Yasuda, M Kimura, Y Okano and Y Kawada
Department of Urology, Gifu University School of Medicine, Japan.

We determined partial sequences of the gyrA and parC genes of the fluoroquinolone-susceptible strain ATCC 27853 and 22 clinical isolates of Pseudomonas aeruginosa. While a single amino acid change in GyrA with or without a change in ParC was found in 14 isolates with decreased susceptibility to fluoroquinolones, 3 higher-level fluoroquinolone-resistant isolates had a double amino acid change in GyrA and a single amino acid change in ParC.


This article has been cited by other articles:

  • Leavis, H. L., Willems, R. J. L., Top, J., Bonten, M. J. M. (2006). High-Level Ciprofloxacin Resistance from Point Mutations in gyrA and parC Confined to Global Hospital-Adapted Clonal Lineage CC17 of Enterococcus faecium.. J. Clin. Microbiol. 44: 1059-1064 [Abstract] [Full Text]  
  • Giraud, E., Blanc, G., Bouju-Albert, A., Weill, F.-X., Donnay-Moreno, C. (2004). Mechanisms of quinolone resistance and clonal relationship among Aeromonas salmonicida strains isolated from reared fish with furunculosis. J Med Microbiol 53: 895-901 [Abstract] [Full Text]  
  • Hocquet, D., Bertrand, X., Kohler, T., Talon, D., Plesiat, P. (2003). Genetic and Phenotypic Variations of a Resistant Pseudomonas aeruginosa Epidemic Clone. Antimicrob. Agents Chemother. 47: 1887-1894 [Abstract] [Full Text]  
  • Onodera, Y., Okuda, J., Tanaka, M., Sato, K. (2002). Inhibitory Activities of Quinolones against DNA Gyrase and Topoisomerase IV of Enterococcus faecalis. Antimicrob. Agents Chemother. 46: 1800-1804 [Abstract] [Full Text]  
  • Reinhardt, A. K., Bebear, C. M., Kobisch, M., Kempf, I., Gautier-Bouchardon, A. V. (2002). Characterization of Mutations in DNA Gyrase and Topoisomerase IV Involved in Quinolone Resistance of Mycoplasma gallisepticum Mutants Obtained In Vitro. Antimicrob. Agents Chemother. 46: 590-593 [Abstract] [Full Text]  
  • Akasaka, T., Tanaka, M., Yamaguchi, A., Sato, K. (2001). Type II Topoisomerase Mutations in Fluoroquinolone-Resistant Clinical Strains of Pseudomonas aeruginosa Isolated in 1998 and 1999: Role of Target Enzyme in Mechanism of Fluoroquinolone Resistance. Antimicrob. Agents Chemother. 45: 2263-2268 [Abstract] [Full Text]  
  • Lomovskaya, O., Warren, M. S., Lee, A., Galazzo, J., Fronko, R., Lee, M., Blais, J., Cho, D., Chamberland, S., Renau, T., Leger, R., Hecker, S., Watkins, W., Hoshino, K., Ishida, H., Lee, V. J. (2001). Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy. Antimicrob. Agents Chemother. 45: 105-116 [Abstract] [Full Text]  
  • Lomovskaya, O., Lee, A., Hoshino, K., Ishida, H., Mistry, A., Warren, M. S., Boyer, E., Chamberland, S., Lee, V. J. (1999). Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 43: 1340-1346 [Abstract] [Full Text]  
  • Akasaka, T., Onodera, Y., Tanaka, M., Sato, K. (1999). Cloning, Expression, and Enzymatic Characterization of Pseudomonas aeruginosa Topoisomerase IV. Antimicrob. Agents Chemother. 43: 530-536 [Abstract] [Full Text]  
  • Takenouchi, T., Sakagawa, E., Sugawara, M. (1999). Detection of gyrA Mutations among 335 Pseudomonas aeruginosa Strains Isolated in Japan and Their Susceptibilities to Fluoroquinolones. Antimicrob. Agents Chemother. 43: 406-409 [Abstract] [Full Text]  
  • Mouneimné, H., Robert, J., Jarlier, V., Cambau, E. (1999). Type II Topoisomerase Mutations in Ciprofloxacin-Resistant Strains of Pseudomonas aeruginosa. Antimicrob. Agents Chemother. 43: 62-66 [Abstract] [Full Text]  
  • Piddock, L. J. V., Johnson, M., Ricci, V., Hill, S. L. (1998). Activities of New Fluoroquinolones against Fluoroquinolone-Resistant Pathogens of the Lower Respiratory Tract. Antimicrob. Agents Chemother. 42: 2956-2960 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»