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Antimicrob. Agents Chemother., 10 1997, 2292-2294, Vol 41, No. 10
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Pharmacokinetic study of cefodizime and ceftriaxone in sera and bones of patients undergoing hip arthroplasty

F Scaglione, G De Martini, L Peretto, R Ghezzi, M Baratelli, MM Arcidiacono and F Fraschini
Department of Pharmacology, Chemotherapy and Toxicology, Faculty of Medicine, University of Milan, Italy. Chemio@imiucca.csi.unimi.it

The study was carried out to determine the concentrations of cefodizime (single 2-g intravenous [i.v.] dose) and ceftriaxone (single 2-g i.v. dose) in the sera and bones of 42 patients (18 women and 24 men) undergoing hip arthroplasty. The concentrations of cefodizime and ceftriaxone in cancellous and cortical bone appear to be related to the free levels in serum but not to the total levels in serum, so the concentrations of cephalosporins in bone must be compared with the free concentrations in serum. Both drugs diffuse well into bone, with concentrations exceeding the MIC at which 90% of the major pathogenic infecting organisms are inhibited.


This article has been cited by other articles:

  • Lovering, A. M., Walsh, T. R., Bannister, G. C., MacGowan, A. P. (2001). The penetration of ceftriaxone and cefamandole into bone, fat and haematoma and relevance of serum protein binding to their penetration into bone. J Antimicrob Chemother 47: 483-486 [Abstract] [Full Text]  


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