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Antimicrob. Agents Chemother., 10 1997, 2312-2316, Vol 41, No. 10
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Comparative in vitro activities of trovafloxacin (CP-99,219) against 221 aerobic and 217 anaerobic bacteria isolated from patients with intra-abdominal infections

DM Citron and MD Appleman
Microbial Research Laboratory, LAC+USC Medical Center, Los Angeles, California 90033, USA.

Four hundred thirty-eight bacteria cultured from specimens of patients with serious intra-abdominal infections were tested by agar dilution against trovafloxacin and other quinolones and antimicrobial agents. Trovafloxacin inhibited 435 strains (99.3%) at < or =2 microg/ml. All the quinolones had similar activities against Enterobacteriaceae and Pseudomonas sp., but trovafloxacin showed superior activities against streptococci, enterococci, and anaerobic organisms. Because of its excellent in vitro activities against diverse bacteria, trovafloxacin has potential use as a single agent for polymicrobial infections.

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