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Antimicrob. Agents Chemother., Nov 1997, 2540-2543, Vol 41, No. 11
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Differential selection of multidrug efflux systems by quinolones in Pseudomonas aeruginosa

T Kohler, M Michea-Hamzehpour, P Plesiat, AL Kahr and JC Pechere
Department of Genetics and Microbiology, Centre Medical Universitaire, Geneva, Switzerland. Thilo.Kohler@medecine.unige.ch

Resistance mechanisms selected after in vitro exposure to 12 quinolones were analyzed for Pseudomonas aeruginosa. Efflux-type mutants were predominant. Quinolones differed in their ability to select a particular efflux system. While the newer fluoroquinolones favored the MexCD-OprJ system, the older quinolones selected exclusively the MexEF- OprN or MexAB-OprM systems. A protonable C-7 substituent in combination with a C-6 fluorine atom is a structural determinant of quinolones involved in efflux pump substrate specificity.


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