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Antimicrob. Agents Chemother., 11 1997, 2544-2546, Vol 41, No. 11
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Improved antimicrobial activity of DU-6859a, a new fluoroquinolone, against quinolone-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates with alterations in GyrA and ParC proteins

T Deguchi, M Yasuda, , M Nakano, S Ozeki, E Kanematsu, Y Nishino and Y Kawada
Department of Urology, Gifu University School of Medicine, Japan.

MICs of DU-6859a, a novel fluoroquinolone, for 18 Klebsiella pneumoniae isolates and 21 Enterobacter cloacae isolates with altered GyrA or altered GyrA and ParC ranged from < or =0.025 to 6.25 microg/ml and from 0.1 to 3.13 microg/ml, respectively. Based on the MICs at which 90% of the isolates were inhibited for these strains of K. pneumoniae and E. cloacae, DU-6859a exhibited 16- to 256-fold-greater activity than currently available fluoroquinolones.

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