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Antimicrob. Agents Chemother., 12 1997, 2760-2762, Vol 41, No. 12
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Comparison of in vitro antifungal susceptibilities of conidia and hyphae of filamentous fungi

J Guarro, C Llop, C Aguilar and I Pujol
Unitat de Microbiologia, Facultat de Medicina, Universitat Rovira i Virgili, Reus, Tarragona, Spain.

The MICs and minimum fungicidal concentrations (MFCs) of amphotericin B, fluconazole, ketoconazole, flucytosine, miconazole, and itraconazole for 12 isolates of filamentous opportunistic fungi (Scopulariopsis sp., Paecilomyces sp., Cladosporium spp., and Cladophialophora sp.) were determined by a broth microdilution method with hyphal and conidial inocula. With hyphal inocula MICs and MFCs were practically always substantially higher. Only 25% of the 60 MIC comparisons showed discrepancies of twofold or less, while the remaining comparisons showed much larger differences.


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