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Antimicrobial Agents and Chemotherapy, May 1997, 1134-1136, Vol 41, No. 5
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293

E Charpentier and P Courvalin
Unite des Agents Antibacteriens, Centre National de la Recherche Scientifique, Institut Pasteur, Paris, France.

The sequence of the trimethoprim resistance gene of the 3.7-kb plasmid (pIP823) that confers high-level resistance (MIC, 1,024 microg/ml) to Listeria monocytogenes BM4293 was determined. The gene was identical to dfrD recently detected in Staphylococcus haemolyticus MUR313. The corresponding protein, S2DHFR, represents the second class of high- level trimethoprim-resistant dihydrofolate reductase identified in gram- positive bacteria. We propose that trimethoprim resistance in L. monocytogenes BM4293 could originate in staphylococci.


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