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Antimicrobial Agents and Chemotherapy, May 1997, 1140-1142, Vol 41, No. 5
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

Multiple antibiotic resistance in Stenotrophomonas maltophilia

A Alonso and JL Martinez
Banco de Celulas, Centro Nacional de Biotecnologia (CSIC), Campus UAM, Cantoblanco, Madrid, Spain.

A cryptic multidrug resistance (MDR) system in Stenotrophomonas maltophilia, the expression of which is selectable by tetracycline, is described. Tetracycline resistance was the consequence of active efflux of the antibiotic, and it was associated with resistance to quinolones and chloramphenicol, but not to aminoglycosides or beta-lactam antibiotics. MDR is linked to the expression of an outer membrane protein (OMP54) both in a model system and in multidrug-resistant clinical isolates.


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