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Antimicrobial Agents and Chemotherapy, Jul 1997, 1607-1608, Vol 41, No. 7
Copyright © 1997 by the American Society for Microbiology. All rights reserved.

In vitro synergy testing of clarithromycin and 14-hydroxyclarithromycin with amoxicillin or bismuth subsalicylate against Helicobacter pylori

JM Meyer, S Ryu, SL Pendland and LH Danziger
College of Pharmacy, University of Illinois, Chicago 60612, USA.

The activity of clarithromycin-14-hydroxyclarithromycin (2:1 ratio) and bismuth subsalicylate or amoxicillin against Helicobacter pylori was determined by the checkerboard technique in vitro. Clarithromycin-14- hydroxyclarithromycin and amoxicillin resulted in additive effects in 7 of 22 isolates, compared to 14 of 22 isolates when bismuth subsalicylate was substituted for amoxicillin. Synergy was not demonstrated and is probably not responsible for the clinical success of treatment combinations containing clarithromycin.

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