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Antimicrobial Agents and Chemotherapy, January 1998, p. 184-187, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Comparison of CO2 Generation (BACTEC) and Viable-Count Methods To Determine the Postantibiotic Effect of Antimycobacterial Agents against Mycobacterium avium Complex

George G. Zhanel,1,2,3,4,* Marilyn H. Saunders,1 Joyce N. Wolfe,3 Daryl J. Hoban,1,3 James A. Karlowsky,1,2,3 and Amin M. Kabani1,3,4

Department of Medical Microbiology1 and Faculty of Pharmacy,2 University of Manitoba, and Departments of Clinical Microbiology3 and Medicine,4 Health Sciences Centre, Winnipeg, Manitoba, Canada

Received 31 July 1997/Returned for modification 27 August 1997/Accepted 27 October 1997

The postantibiotic effects (PAEs) of antimycobacterial agents determined with a BACTEC TB-460 instrument (CO2 production) and by a traditional viable-count method against Mycobacterium avium complex (MAC) were not significantly different (P > 0.05). The longest PAEs following a 2-h exposure to 2× the MIC were induced by amikacin (10.3 h), rifampin (9.7 h), and rifabutin (9.5 h), while the shortest PAEs resulted from clofazimine (1.7 h) and ethambutol (1.1 h) exposure. CO2 generation is a valid and efficient means of determining in vitro PAEs against MAC.

* Corresponding author. Mailing address: Health Sciences Centre, MS673-820 Sherbrook St., Winnipeg, Manitoba R3A 1R9, Canada. Phone: (204) 787-4902. Fax: (204) 787-4699. E-mail: ggzhanel{at}pcs.mb.ca.

Antimicrobial Agents and Chemotherapy, January 1998, p. 184-187, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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