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Antimicrobial Agents and Chemotherapy, January 1998, p. 188-189, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Treatment of Enterococcal Pyelonephritis with Trovafloxacin and Rifampin: In Vitro-In Vivo Contrast

J. Z. Montgomerie1,2,* and D. G. Schick1

Department of Medicine, Rancho Los Amigos Medical Center, Downey,1 and School of Medicine, University of Southern California, Los Angeles,2 California

Received 23 May 1997/Returned for modification 7 August 1997/Accepted 24 October 1997

The in vitro bactericidal interaction of trovafloxacin and rifampin against Enterococcus spp. has indicated that antagonism occurs between these two antimicrobial agents. This drug combination was examined in vivo in rats with experimental pyelonephritis. The rats received trovafloxacin, rifampin, or both drugs. On the basis of the mean log10 CFU of Enterococcus faecalis from the kidneys, there was no evidence that trovafloxacin and rifampin were antagonistic in vivo.

* Corresponding author. Mailing address: Department of Medicine, Rancho Los Amigos Medical Center, 7601 East Imperial Highway, Downey, CA 90242. Phone: (562) 401 7461. Fax: (562) 803 6145. E-mail: Johnmont{at}hsc.usc.edu.

Antimicrobial Agents and Chemotherapy, January 1998, p. 188-189, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.




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