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Antimicrobial Agents and Chemotherapy, January 1998, p. 199-201, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Concentrations of Cefpirome in Cerebrospinal Fluid of Children with Bacterial Meningitis after a Single Intravenous Dose

Ian R. Friedland,1,* Eric Sultan,2 Karl H. Lehr,3 and Bernard Lenfant2

Department of Pediatrics, Baragwanath Hospital and the University of the Witwatersrand, Johannesburg, South Africa1; Hoechst Marion Roussel, Romainville, France2; and Hoechst Marion Roussel, Frankfurt, Germany3

Received 24 March 1997/Returned for modification 27 August 1997/Accepted 21 October 1997

A single intravenous dose of cefpirome, 50 mg/kg, was administered to 15 children with bacterial meningitis 24 to 48 h after initiation of standard antibiotic and steroid therapy. Cefpirome concentrations in serum and cerebrospinal fluid were determined at selected time intervals. The mean (standard deviation) peak concentration in cerebrospinal fluid (n = 5) was 10.8 (7.8) µg/ml. Drug concentrations in cerebrospinal fluid above the MIC for Streptococcus pneumoniae at which 90% of the isolates were inhibited were found 2, 4, and 8 h after the dose of cefpirome was given. The penetration of cefpirome into cerebrospinal fluid compares favorably with that of other extended-spectrum cephalosporins and suggests that this agent would be useful in the therapy of childhood meningitis, including cases caused by drug-resistant S. pneumoniae.

* Corresponding author. Present address: Department of Pediatrics, Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75235-9063. Phone: 214-648-3439. Fax: 214-648-2961. E-mail: ifried{at}mednet.swmed.edu.

Antimicrobial Agents and Chemotherapy, January 1998, p. 199-201, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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