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Antimicrobial Agents and Chemotherapy, January 1998, p. 37-39, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Therapeutic Effects of Water-Soluble Echinocandin Compounds on Pneumocystis Pneumonia in Mice

Takahisa Furuta,1,* Hideyuki Muramatsu,2 Akihiko Fujie,2 Shiro Fujihira,3 Noor Rain Abudullah,4 and Somei Kojima1

Department of Parasitology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108,1 Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 5-2-3 Tokodai, Tsukuba-shi, Ibaraki, 300-26,2 and Toxicology Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., 2-1-6 Kashima, Yodogawa-ku, Osaka-shi, Osaka, 532,3 Japan, and Biotechnology Center, Institute for Medical Research, Jalan Pahang 50588, Kuala Lumpur, Malaysia4

Received 14 April 1997/Returned for modification 14 July 1997/Accepted 17 October 1997

The therapeutic effectiveness of water-soluble echinocandin compounds obtained from Coleophoma empetri F-11899, which has a strong inhibitory effect on the growth of fungi, was examined in nude mice with experimental Pneumocystis pneumonia. The studies demonstrated the potential usefulness of the compounds.

* Corresponding author. Mailing address: Department of Parasitology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108, Japan. Phone: 81-3-5449-5378. Fax: 81-3-5449-5410. E-mail: furuta{at}hgc.ims.u-tokyo.ac.jp.

Antimicrobial Agents and Chemotherapy, January 1998, p. 37-39, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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