This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsuji, M.
Right arrow Articles by Yamaguchi, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsuji, M.
Right arrow Articles by Yamaguchi, K.

 Previous Article  |  Next Article 

Antimicrobial Agents and Chemotherapy, January 1998, p. 94-99, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro and In Vivo Antibacterial Activities of S-4661, a New Carbapenem

Masakatsu Tsuji,* Yoshikazu Ishii, Akira Ohno, Shuichi Miyazaki, and Keizo Yamaguchi

Department of Microbiology, Toho University School of Medicine, 5-21-16, Omori-nishi, Ota-ku, Tokyo 143, Japan

Received 18 April 1997/Returned for modification 25 August 1997/Accepted 20 October 1997

The in vitro and in vivo antibacterial activities of S-4661, a new 1beta -methylcarbapenem, were compared with those of imipenem, meropenem, biapenem, cefpirome, and ceftazidime. The activity of S-4661 against methicillin-susceptible staphylococci and streptococci was comparable to that of imipenem, with an MIC at which 90% of the strains tested were inhibited (MIC90) equal to 0.5 µg/ml or less. S-4661 was highly active against members of the family Enterobacteriaceae, Haemophilus influenzae, and Moraxella catarrhalis, with MIC90s ranging from 0.032 to 0.5 µg/ml. Against imipenem-resistant Pseudomonas aeruginosa, S-4661 was the most active among test agents (MIC90, 8 µg/ml). Furthermore, S-4661 displayed a high degree of activity against many ceftazidime-, ciprofloxacin-, and gentamicin-resistant isolates of P. aeruginosa. The in vivo efficacy of S-4661 against experimentally induced infections in mice caused by gram-positive and gram-negative bacteria, including penicillin-resistant Streptococcus pneumoniae and drug-resistant P. aeruginosa, reflected its potent in vitro activity and high levels in plasma in mice. We conclude that S-4661 is a promising new carbapenem for the treatment of infections caused by gram-positive and -negative bacteria, including penicillin-resistant S. pneumoniae and drug-resistant P. aeruginosa.


* Corresponding author. Present address: Department of Antimicrobial Program, Discovery Research Laboratories II, Shionogi & Co. Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka 561, Japan. Phone: 81 (6) 331-8081. Fax: 81 (6) 331-8612. E-mail: masakatsu.tsuji{at}shionogi.co.jp.


Antimicrobial Agents and Chemotherapy, January 1998, p. 94-99, Vol. 42, No. 1
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.



This article has been cited by other articles:

  • Lister, P. D., Wolter, D. J., Hanson, N. D. (2009). Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms. Clin. Microbiol. Rev. 22: 582-610 [Abstract] [Full Text]  
  • Wagenlehner, F. M. E., Wagenlehner, C., Redman, R., Weidner, W., Naber, K. G. (2009). Urinary Bactericidal Activity of Doripenem versus That of Levofloxacin in Patients with Complicated Urinary Tract Infections or Pyelonephritis. Antimicrob. Agents Chemother. 53: 1567-1573 [Abstract] [Full Text]  
  • Pillar, C. M., Torres, M. K., Brown, N. P., Shah, D., Sahm, D. F. (2008). In Vitro Activity of Doripenem, a Carbapenem for the Treatment of Challenging Infections Caused by Gram-Negative Bacteria, against Recent Clinical Isolates from the United States. Antimicrob. Agents Chemother. 52: 4388-4399 [Abstract] [Full Text]  
  • Wexler, H. M., Engel, A. E., Glass, D., Li, C. (2005). In Vitro Activities of Doripenem and Comparator Agents against 364 Anaerobic Clinical Isolates. Antimicrob. Agents Chemother. 49: 4413-4417 [Abstract] [Full Text]  
  • Koga, T., Abe, T., Inoue, H., Takenouchi, T., Kitayama, A., Yoshida, T., Masuda, N., Sugihara, C., Kakuta, M., Nakagawa, M., Shibayama, T., Matsushita, Y., Hirota, T., Ohya, S., Utsui, Y., Fukuoka, T., Kuwahara, S. (2005). In Vitro and In Vivo Antibacterial Activities of CS-023 (RO4908463), a Novel Parenteral Carbapenem. Antimicrob. Agents Chemother. 49: 3239-3250 [Abstract] [Full Text]  
  • Chen, Y., Garber, E., Zhao, Q., Ge, Y., Wikler, M. A., Kaniga, K., Saiman, L. (2005). In Vitro Activity of Doripenem (S-4661) against Multidrug-Resistant Gram-Negative Bacilli Isolated from Patients with Cystic Fibrosis. Antimicrob. Agents Chemother. 49: 2510-2511 [Abstract] [Full Text]  
  • Brown, S. D., Traczewski, M. M. (2005). Comparative in vitro antimicrobial activity of a new carbapenem, doripenem: tentative disc diffusion criteria and quality control. J Antimicrob Chemother 55: 944-949 [Abstract] [Full Text]  
  • Mushtaq, S., Ge, Y., Livermore, D. M. (2004). Doripenem versus Pseudomonas aeruginosa In Vitro: Activity against Characterized Isolates, Mutants, and Transconjugants and Resistance Selection Potential. Antimicrob. Agents Chemother. 48: 3086-3092 [Abstract] [Full Text]  
  • Mushtaq, S., Ge, Y., Livermore, D. M. (2004). Comparative Activities of Doripenem versus Isolates, Mutants, and Transconjugants of Enterobacteriaceae and Acinetobacter spp. with Characterized {beta}-Lactamases. Antimicrob. Agents Chemother. 48: 1313-1319 [Abstract] [Full Text]  
  • Ge, Y., Wikler, M. A., Sahm, D. F., Blosser-Middleton, R. S., Karlowsky, J. A. (2004). In Vitro Antimicrobial Activity of Doripenem, a New Carbapenem. Antimicrob. Agents Chemother. 48: 1384-1396 [Abstract] [Full Text]  
  • Tsuji, M., Takema, M., Miwa, H., Shimada, J., Kuwahara, S. (2003). In Vivo Antibacterial Activity of S-3578, a New Broad-Spectrum Cephalosporin: Methicillin-Resistant Staphylococcus aureus and Pseudomonas aeruginosa Experimental Infection Models. Antimicrob. Agents Chemother. 47: 2507-2512 [Abstract] [Full Text]  
  • Tsuji, M., Matsuda, H., Miwa, H., Miyazaki, S. (2003). Antimicrobial-induced release of endotoxin from Pseudomonas aeruginosa: comparison of in vitro and animal models. J Antimicrob Chemother 51: 353-359 [Abstract] [Full Text]  
  • Mikamo, H., Izumi, K., Hua, Y. X., Hayasaki, Y., Sato, Y., Tamaya, T. (2000). In vitro and in vivo antibacterial activities of a new injectable carbapenem, S-4661, against gynaecological pathogens. J Antimicrob Chemother 46: 471-474 [Abstract] [Full Text]  
  • Mimoz, O., Leotard, S., Jacolot, A., Padoin, C., Louchahi, K., Petitjean, O., Nordmann, P. (2000). Efficacies of Imipenem, Meropenem, Cefepime, and Ceftazidime in Rats with Experimental Pneumonia Due to a Carbapenem-Hydrolyzing beta -Lactamase-Producing Strain of Enterobacter cloacae. Antimicrob. Agents Chemother. 44: 885-890 [Abstract] [Full Text]  
  • Weiss, W. J., Petersen, P. J., Jacobus, N. V., Lin, Y.-I, Bitha, P., Testa, R. T. (1999). In Vitro Activities of Aminomethyl-Substituted Analogs of Novel Tetrahydrofuranyl Carbapenems. Antimicrob. Agents Chemother. 43: 454-459 [Abstract] [Full Text]  
  • Weiss, W. J., Mikels, S. M., Petersen, P. J., Jacobus, N. V., Bitha, P., Lin, Y.-I., Testa, R. T. (1999). In Vivo Activities of Peptidic Prodrugs of Novel Aminomethyl Tetrahydrofuranyl-1beta -Methylcarbapenems. Antimicrob. Agents Chemother. 43: 460-464 [Abstract] [Full Text]