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Antimicrobial Agents and Chemotherapy, October 1998, p. 2747-2748, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

In Vitro Susceptibility of Coxiella burnetii to Trovafloxacin in Comparison with Susceptibilities to Pefloxacin, Ciprofloxacin, Ofloxacin, Doxycycline, and Clarithromycin

Achilleas Gikas,* Ioanna Spyridaki, Anna Psaroulaki, Diamantis Kofterithis, and Yannis Tselentis

Clinical Bacteriology, Parasitology, Zoonoses, and Geographical Medicine, University Hospital of Heraklion, 1352/71110 Crete, Greece

Received 24 April 1998/Returned for modification 28 May 1998/Accepted 16 July 1998

The antibiotic susceptibilities of eight Greek isolates of Coxiella burnetii to trovafloxacin were determined by the shell vial assay. MICs of trovafloxacin and ofloxacin ranged from 1 to 2 µg/ml, those of pefloxacin ranged from 1 to 4 µg/ml, those of ciprofloxacin ranged from 4 to 8 µg/ml, those of doxycycline ranged from 1 to 2 µg/ml, and those of clarithromycin ranged from 2 to 4 µg/ml. Trovafloxacin exhibited no activity against C. burnetii at 4 µg/ml.

* Corresponding author. Mailing address: Clinical Bacteriology, Parasitology, and Geographical Medicine, University Hospital of Heraklion, 1352/71110 Crete, Greece. Phone: 30-81-392360. Fax: 30-81-392847. E-mail: achille{at}edu.uch.gr.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2747-2748, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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