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Antimicrobial Agents and Chemotherapy, October 1998, p. 2749-2751, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Explaining the Bias in the 23S rRNA Gene Mutations Associated with Clarithromycin Resistance in Clinical Isolates of Helicobacter pylori

Y. J. Debets-Ossenkopp,1,* A. B. Brinkman,1 E. J. Kuipers,2 C. M. J. E. Vandenbroucke-Grauls,1 and J. G. Kusters1

Departments of Clinical Microbiology and Infection Control1 and Gastroenterology,2 University Hospital Vrije Universiteit, Amsterdam, The Netherlands

Received 26 January 1998/Returned for modification 22 April 1998/Accepted 16 July 1998

A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance may result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.

* Corresponding author. Mailing address: Department of Clinical Microbiology and Infection Control, University Hospital Vrije Universiteit, P.O. Box 7057, 1007 MB, Amsterdam, The Netherlands. Phone: 31-20-4440488. Fax: 31-20-4440473. E-mail: yj.debets{at}azvu.nl.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2749-2751, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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