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Antimicrobial Agents and Chemotherapy, October 1998, p. 2756-2758, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

A New Approach for Early Assessment of the Epileptogenic Potential of Quinolones

Annie Delon, Claudine Pariat, Philippe Courtois, Serge Bouquet, and William Couet*

UPRES-EA 1223, Faculté de Médecine et Pharmacie, Poitiers, France

Received 28 January 1998/Returned for modification 7 May 1998/Accepted 20 July 1998

The epileptogenic potential of pefloxacin and norfloxacin, two quinolone antibiotics, was investigated in vivo in three different animal species by measuring drug concentrations in cerebrospinal fluid (CSF), which is part of the biophase, at the onset of convulsions. Interestingly, the pefloxacin-to-norfloxacin concentration ratios in CSF were virtually constant across the species (7.0, 6.6, and 6.0 in mice, rats, and rabbits, respectively), suggesting that this approach could be used to predict the relative epileptogenic potential of quinolones in humans.

* Corresponding author. Mailing address: Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Médecine & Pharmacie, 34 rue du Jardin des Plantes, 86005 Poitiers Cédex, France. Phone: (33-5) 49.45.43.79. Fax: (33-5) 49.45.43.78. E-mail: William.Couet{at}campus.univ-poitiers.fr.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2756-2758, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Smolders, I., Gousseau, C., Marchand, S., Couet, W., Ebinger, G., Michotte, Y. (2002). Convulsant and Subconvulsant Doses of Norfloxacin in the Presence and Absence of Biphenylacetic Acid Alter Extracellular Hippocampal Glutamate but Not Gamma-Aminobutyric Acid Levels in Conscious Rats. Antimicrob. Agents Chemother. 46: 471-477 [Abstract] [Full Text]  
  • Delon, A., Bouquet, S., Huguet, F., Brunet, V., Courtois, P., Couet, W. (1999). Pharmacokinetic-Pharmacodynamic Contributions to the Convulsant Activity of Fluoroquinolones in Rats. Antimicrob. Agents Chemother. 43: 1511-1515 [Abstract] [Full Text]  


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