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Antimicrobial Agents and Chemotherapy, October 1998, p. 2765-2767, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

PMX-622 (Polymyxin B-Dextran 70) Does Not Alter In Vitro Activities of 11 Antimicrobial Agents

Peter C. Fuchs,* Arthur L. Barry, and Steven D. Brown

The Clinical Microbiology Institute, Wilsonville, Oregon 97070

Received 23 February 1998/Returned for modification 26 May 1998/Accepted 3 July 1998

Because of its capacity to neutralize the lethality of gram-negative bacterial endotoxic lipopolysaccharides, PMX-622 (polymyxin B bound to dextran 70) is being developed for possible adjunctive therapy of gram-negative sepsis. In this study, it was determined that the in vitro antimicrobial activity of PMX-622 was minimal and that it does not interfere with the in vitro antimicrobial activity of 11 antibiotics commonly used to treat gram-negative infections.

* Corresponding author. Mailing address: 9725 SW Commerce Circle, Suite A1, Wilsonville, OR 97070. Phone: (503) 682-3232. Fax: (503) 682-2065. E-mail: cmi{at}hevanet.com.

Antimicrobial Agents and Chemotherapy, October 1998, p. 2765-2767, Vol. 42, No. 10
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Gales, A. C., Reis, A. O., Jones, R. N. (2001). Contemporary Assessment of Antimicrobial Susceptibility Testing Methods for Polymyxin B and Colistin: Review of Available Interpretative Criteria and Quality Control Guidelines. J. Clin. Microbiol. 39: 183-190 [Abstract] [Full Text]  


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