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Antimicrobial Agents and Chemotherapy, November 1998, p. 3002-3005, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.

Antimicrobial Susceptibility of Bacteria Isolated from Orthopedic Implants following Revision Hip Surgery

Michael M. Tunney,1,2 Gordon Ramage,1 Sheila Patrick,1 James R. Nixon,3 Philip G. Murphy,4 and Sean P. Gorman2,*

Department of Microbiology and Immunobiology, School of Clinical Medicine, The Queen's University of Belfast, Belfast BT12 6BN,1 School of Pharmacy, The Queen's University of Belfast,2 and Department of Bacteriology, Belfast City Hospital,4 Belfast BT9 7BL, and Withers Orthopaedic Centre, Musgrave Park Hospital, Belfast BT9 7JB,3 United Kingdom

Received 27 February 1998/Returned for modification 23 July 1998/Accepted 13 August 1998

The susceptibilities of 49 isolates recovered from orthopedic implants to seven antimicrobial agents were evaluated by the broth microdilution method. Ciprofloxacin and vancomycin were more active than gentamicin, representing aminoglycosides which are routinely incorporated into bone cement, and also more active than the peroperative antimicrobial agents cefamandole and erythromycin. The use of ciprofloxacin and vancomycin in vivo, therefore, warrants further evaluation.

* Corresponding author. Mailing address: School of Pharmacy, The Queen's University of Belfast, 97 Lisburn Rd., Belfast BT9 7BL, United Kingdom. Phone: 01232-272017. Fax: 01232-247794. E-mail: s.gorman{at}qub.ac.uk.

Antimicrobial Agents and Chemotherapy, November 1998, p. 3002-3005, Vol. 42, No. 11
0066-4804/98/$04.00+0
Copyright © 1998, American Society for Microbiology. All rights reserved.


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